Methods :
 We conducted a comprehensive literature review searching PubMed, Google Scholar, and Web of Science databases. Studies investigating TKM-CD interactions were identified and analyzed. Network analysis was performed to visualize interaction patterns.

Results : 
From 2,011 initially identified studies, 27 met inclusion criteria. Studies were predominantly from Korea and Japan. Pharmacokinetic studies were most common, followed by pharmacodynamic and combined studies. Research methods were equally distributed between in vivo and clinical studies. Gamisoyo-san (GS) and Banxiaxiexin-tang (BST) were most frequently studied (6 studies each). Anticancer agents were the most studied conventional drugs. Network analysis revealed 29 nodes with 27 interactions, showing GS and BST as central hubs (degree centrality = 6). Major interaction patterns involved digestive TKM formulas with anticancer agents.

Conclusion :
 This study provides the first comprehensive mapping of TKM-CD interactions. Anticancer drug combinations require particular attention, while certain combinations like BST with chemotherapy showed beneficial synergistic effects. These findings inform evidence-based clinical decision-making for integrative medicine practices.

Funding : 
Funded by Korea Health Industry Development Institute (KHIDI), Ministry of Health & Welfare, Republic of Korea (RS-2023-KH139287).